Assessment of mobile applications for drug incompatibility detection: an integrative review
DOI:
https://doi.org/10.30968/jhphs.2025.164.1377Abstract
Objective: To evaluate the availability and quality of mobile applications designed for detecting drug incompatibilities. Methods: An integrative review was conducted on the Google Play Store and Apple App Selected. Terms in Portuguese, English, and Spanish related to “drug incompatibility” were used. Duplicate applications, applications in languages other than Portuguese, English, and Spanish, or applications that did not directly address drug incompatibilities (i.e., provided only general drug information) were excluded. The apps were assessed using the Portuguese version of the Mobile App Rating Scale (MARS) scale by two independent pharmacists. Results: Among 244 initially retrieved apps, only three met the inclusion criteria: Micromedex® IV Compatibility, Medscape, and Compatibilidad fármacos IV. Micromedex® achieved the highest average MARS score (4.51/5), particularly in information (4.75) and aesthetics (4.6), though it requires institutional subscription. The other two offered limited, monograph-based drug incompatibilities information. None were available in Portuguese, and only one was free. Conclusion: The analysis highlighted a lack of free mobile applications, in Portuguese and adapted to the Brazilian context, for drug incompatibilities detection, which reinforces the need to develop accessible digital applications to support clinical practice and patient safety.
Downloads
References
1. Black AD, Car J, Pagliari C, et al. The impact of eHealth on the quality and safety of health care: a systematic overview. PLoS Med. 2011;8(1):e1000387. doi:10.1371/journal.pmed.1000387
2. Dymyt M. The role of eHealth in the management of patient safety. J e-Health Manag. 2020;(2020):341252. doi:10.5171/2020.341252
3. Jandoo T. WHO guidance for digital health: What it means for researchers. Digit Health. 2020;6:2055207619898984. doi:10.1177/2055207619898984
4. Bates DW, Spell N, Cullen DJ, et al. The costs of adverse drug events in hospitalized patients. Adverse Drug Events Prevention Study Group. JAMA. 1997;277(4):307-311. doi:10.1001/jama.1997.03540280045032
5. Abu SF, Shafie AA, Chandriah H. Cost estimations of managing adverse drug reactions in hospitalized patients: a systematic review of study methods and their influences. Pharmacoepidemiol. 2023;2(2):120-139. doi:10.3390/pharma2020012
6. Institute of Medicine (US) Committee on Quality of Health Care in America, Kohn LT, Corrigan JM, Donaldson MS, eds. To Err is Human: Building a Safer Health System. Washington (DC): National Academies Press (US); 2000.
7. Robinson EG, Hedna K, Hakkarainen KM, et al. Healthcare costs of adverse drug reactions and potentially inappropriate prescribing in older adults: a population-based study. BMJ Open. 2022;12(9):e062589. doi:10.1136/bmjopen-2022-0625899
8. Reason J. Human error: models and management. BMJ. 2000;320(7237):768-770. doi:10.1136/bmj.320.7237.768
9. Alsharef Z, Abired A. Evaluation of intravenous drug incompatibilities in the intensive care units of Mitiga Military Hospital and Tripoli University Hospital, Tripoli, Libya. Libyan J Med Res. 2023;17(2):1-7. doi: 10.54361/ljmr.v17i2.01
10. Tissot E, Cornette C, Demoly P, et al. Medication errors at the administration stage in an intensive care unit. Intensive Care Med. 1999;25(4):353-359. doi:10.1007/s001340050857
11. Neininger MP, Buchholz P, Frontini R, et al. Incompatible intravenous drug combinations and respective physician and nurse knowledge: a study in routine paediatric intensive care. Eur J Hosp Pharm. 2019;26(4):214-217. doi:10.1136/ejhpharm-2017-001248
12. Sriram S, Aishwarya S, Moithu A, et al. Intravenous Drug Incompatibilities in the Intensive Care Unit of a Tertiary Care Hospital in India: Are they Preventable?. J Res Pharm Pract. 2020;9(2):106-111. doi:10.4103/jrpp.JRPP_20_11
13. Maison O, Tardy C, Cabelguenne D, et al. Drug incompatibilities in intravenous therapy: evaluation and proposition of preventive tools in intensive care and hematology units. Eur J Clin Pharmacol. 2019;75(2):179-187. doi:10.1007/s00228-018-2602-6
14. Négrier L, Martin Mena A, Lebuffe G, et al. Strategies to prevent drug incompatibility during simultaneous multi-drug infusion in intensive care units: a literature review. Eur J Clin Pharmacol. 2021;77(9):1309-1321. doi:10.1007/s00228-021-03112-1
15. Couto D, Barra C, Maria S, et al. Métodos para desenvolvimento de aplicativos móveis em saúde: revisão integrativa da literatura. Texto Contexto Enferm. 2017;26(4):1-12. doi: 10.1590/0104-07072017002260017
16. Gralha SR, Bittencourt ONS. Portuguese translation and validation of the user rating scale for mobile applications in the health area (uMARS). Res Soc Dev. 2023;12(6):e8912642056. doi:10.33448/rsd-v12i6.42056
17. Kim BY, Sharafoddini A, Tran N, et al. Consumer Mobile Apps for Potential Drug-Drug Interaction Check: Systematic Review and Content Analysis Using the Mobile App Rating Scale (MARS). JMIR Mhealth Uhealth. 2018;6(3):e74. doi:10.2196/mhealth.8613
18. Maciel NS, Ferreira DS, Sousa VTS, et al. Qualidade de aplicativos móveis sobre prevenção e controle da sífilis. Esc Anna Nery. 2022;26:e20210139. doi:10.1590/2177-9465-EAN-2021-0139
19. Shen N, Levitan MJ, Johnson A, et al. Finding a depression app: a review and content analysis of the depression app marketplace. JMIR Mhealth Uhealth. 2015;3(1):e16. doi:10.2196/mhealth.3713
20. Bender JL, Yue RY, To MJ, et al. A lot of action, but not in the right direction: systematic review and content analysis of smartphone applications for the prevention, detection, and management of cancer. J Med Internet Res. 2013;15(12):e287. doi:10.2196/jmir.2661
21. Maia JS, Marin HF. Aplicativos móveis para as sociedades menos favorecidas. Acta Paul Enferm. 2021;34:eAPE02214. doi:10.37689/acta-ape/2021AR02214
22. Pereira CB, Barra DCC, Lanzoni GMM, et al. Contribuições dos aplicativos móveis para o atendimento pré-hospitalar: revisão integrativa. Acta Paul Enferm. 2024;37:eAPE0000172. doi:10.37689/acta-ape/2024AR00001722
23. Breiteneder H, Peng YQ, Agache I, et al. Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma. Allergy. 2020;75(12):3039-3068. doi:10.1111/all.14582
24. Naik N, Hameed BMZ, Sooriyaperakasam N, et al. Transforming healthcare through a digital revolution: A review of digital healthcare technologies and solutions. Front Digit Health. 2022;4:919985. doi:10.3389/fdgth.2022.919985
25. Villarreal-Portillo DA, Huerta-Martínez AI, Vera-Guerrero LS, et al. Qualitative evaluation of the structure, content, and consistency of ten mobile applications providing drug-drug interaction information. Lat Am J Clin Sci Med Technol. 2021;3:106-117. doi:10.34141/LJCS3615670
26. Schneider LR, Pereira RPG, Ferraz L. A prática baseada em evidência no contexto da atenção primária à saúde. Saúde Debate. 2018;42(118):594-605. doi:10.1590/0103-1104201811804
27. White J, Plompen T, Osadnik C, et al. The experience of interpreter access and language discordant clinical encounters in Australian health care: a mixed methods exploration. Int J Equity Health. 2018;17(1):151. doi:10.1186/s12939-018-0865-2
28. Amano T, González-Varo JP, Sutherland WJ. Languages are still a major barrier to global science. PLoS Biol. 2016;14(12):e2000933. doi:10.1371/journal.pbio.2000933
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Authors

This work is licensed under a Creative Commons Attribution 4.0 International License.
The authors hereby transfer, assign, or otherwise convey to JHPHS : (1) the right to grant permission to republish or reprint the stated material, in whole or in part, without a fee; (2) the right to print republish copies for free distribution or sale; and (3) the right to republish the stated material in any format (electronic or printed). In addition, the undersigned affirms that the article described above has not previously been published, in whole or part, is not subject to copyright or other rights except by the author(s), and has not been submitted for publication elsewhere, except as communicated in writing to JHPHS with this document.
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC-BY) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Serlf-archiving policy
This journal permits and encourages authors to post and archive the final pdf of the articles submitted to the journal on personal websites or institutional repositories after publication, while providing bibliographic details that credit its publication in this journal.



